NFASC Antibody | 18-921

NFASC Antibody | 18-921 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2) .

Research Area: Neuroscience

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: SH-SY5Y

Positive Control 2: HeLa

Positive Control 3: HL-60

Positive Control 4: Mouse brain

Positive Control 5: Mouse pancreas

Positive Control 6: Rat brain

Molecular Weight: Observed: 150kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: neurofascin homolog, OTTHUMP00000065324, OTTHUMP00000065323, OTTHUMP00000065319, OTTHUMP00000065316, NRCAML, NF, KIAA0756, FLJ46866, DKFZp686P2250, neurofascin, NFASC

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G) , and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.