NFAT3 (Phospho-S676) polyclonal Antibody | BS64503

NFAT3 (Phospho-S676) polyclonal Antibody | BS64503 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: NFATc4 (nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4) is a member of the nuclear factors of activated T cells DNA-binding transcription complex that influences cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. This complex consists of at least two components: a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL-2 and IL-4. p38 MAP kinase phosphorylates multiple residues in the NFAT homology domain of NFATc4.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NFAT3 (Phospho-S676)  polyclonal Antibody detects endogenous levels of NFAT3 protein only when phosphorylated at Ser676.

Molecular Weight: ~ 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3; NFATC4; NFAT3

Immunogen: Synthetic phosphopeptide derived from human NFAT3 around the phosphorylation site of Serine 676.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Translational Contral elF4 and p70 S6 Kinase,Signaling Pathways Activating p38 MAP KinaseInhibition of Apoptosis,G Protein-coupled Receptors Signaling to MAPK Erk,Cell Cycle G2 M DNA Damage Signaling Pathway,Mitochondrial Control of Apoptosis,