NFH polyclonal Antibody | BS90936

NFH polyclonal Antibody | BS90936 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:200

Background: Neurofilament-H (NF-H), for neurofilament heavy polypeptide, a member of the intermediate filament family, is a major component of neuronal cytoskeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and Actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease and Alzheimer's disease.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NFH polyclonal Antibody detects endogenous levels of NFH protein.

Molecular Weight: 200 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NF-H, NEFH, 200 kDa neurofilament protein, CMT2CC, Nefh, Neurofilament heavy polypeptide 200kDa, Neurofilament heavy polypeptide, Neurofilament triplet H protein, NF H, NF-H, NFH, NFH,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: