NGEF Polyclonal Antibody | E-AB-18859

NGEF Polyclonal Antibody | E-AB-18859 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ARHGEF27, Eph receptor-interacting exchange protein, Eph-interacting exchange protein, EPHEXIN, Ephexin-1, Guanine nucleotide exchange factor, neuronal, Neuronal guanine nucleotide exchange factor, Ngef, NGEF

Application: IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Neuroscience, Signal transduction

Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Concentration: 0.6 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human NGEF

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A