NHEDC2 Antibody (C-term) [APR08737G]

NHEDC2 Antibody (C-term) [APR08737G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NHEDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human NHEDC2.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi- pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5BKR2}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts. {ECO:0000250|UniProtKB:Q5BKR2}

Molecular Weight: 57564

Clone: Polyclonal

Gene Name: SLC9B2

Gene ID: 133308

Function: Na (+) /H (+) antiporter that extrudes Na (+) or Li (+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966) . Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity) . Involved in sperm motility and fertility (By similarity) . It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity) .

Summary: Tissue Location: Widely expressed (PubMed:18508966) . High levels detected in the distal tubules of the kidney nephron (PubMed:18508966) Detected in red blood cells (at protein level) (PubMed:18000046, PubMed:18508966) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Mitochondrial sodium/hydrogen exchanger 9B2, Mitochondrial Na (+) /H (+) exchanger NHA2, Na (+) /H (+) exchanger-like domain-containing protein 2, NHE domain-containing protein 2, Sodium/hydrogen exchanger-like domain-containing protein 2, Solute carrier family 9 subfamily B member 2, SLC9B2, NHA2, NHEDC2