NIAD-4 | 2710

NIAD-4 is a novel class of fluorescent probe, having good blood-brain barrier permeability, specificity to amyloid-β plaques, and "turn-on" bright far-red emission upon Aβ binding. NIAD-4 has a structure geometry that is readily planarized and results in a red shift upon binding to Aβ. The highly polarizable bridge provides a substantial bathochromic shift in both absorption and emission spectra of the agent.

NIAD-4 is a novel class of fluorescent probe, having good blood-brain barrier permeability, specificity to amyloid-β plaques, and "turn-on" bright far-red emission upon Aβ binding.

2710 | NIAD-4 DataSheet

Alternate Name/Synonyms: 2-[[5-[5-(4-hydroxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 868592-56-7

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₀N₂OS₂

Molecular Weight: 334.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An amyloid β (Aβ ) plaque-specific fluorescent probe

MDL Number: N/A

PubChem CID: 9639427

SMILES: C1=CC(=CC=C1C2=CC=C(S2)C3=CC=C(S3)C=C(C#N)C#N)O

InChi: InChI=1S/C18H10N2OS2/c19-10-12(11-20)9-15-5-6-17(22-15)18-8-7-16(23-18)13-1-3-14(21)4-2-13/h1-9,21H

InChi Key: KLFRZDOQQDHVSS-UHFFFAOYSA-N