Nimbolide | 1891

A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.

Nimbolide is a terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis.

1891 | Nimbolide DataSheet

Alternate Name/Synonyms: (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 25990-37-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₀O₇

Molecular Weight: 466.52

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~50 mM) or Ethanol (~ 8 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: MFCD01735386

PubChem CID: 100017

SMILES: CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C

InChi: InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29) 31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17, 21-23H,10-11H2,1-5H3

InChi Key: JZIQWNPPBKFOPT-UHFFFAOYSA-N