Nimustine hydrochloride | B2069

Nimustine is a nitrosourea compound that displays anticancer activity. Nimustine induces DNA cross-linking and double-stranded DNA breaks. Nimustine is clinically used to treat gliomas and may also downregulate expression of DNA ligase IV.

Nimustine is a nitrosourea compound that displays anticancer activity. Nimustine induces DNA cross-linking and double-stranded DNA breaks. Nimustine is clinically used to treat gliomas and may also downregulate expression of DNA ligase IV.

B2069 | Nimustine hydrochloride DataSheet

Alternate Name/Synonyms: 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-1-nitrosourea hydrochloride; NSC-245,382; NSC245,382

Appearance: White to yellow solid

Formulation: N/A

CAS Number: 55661-38-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₁₄Cl₂N₆O₂

Molecular Weight: 309.15

Cell-Permeable?: Yes

Purity: ≥97%

Solubilities: DMSO (>20 mg/ml) or H₂O (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: MFCD01676942

PubChem CID: 91657

SMILES: CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O.Cl

InChi: InChI=1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H

InChi Key: KPMKNHGAPDCYLP-UHFFFAOYSA-N