NIP1 Antibody (BH3 Domain Specific) [AMM06698G]

NIP1 Antibody (BH3 Domain Specific) [AMM06698G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This NIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-127 amino acids from human NIP1.

Cellular Localisation: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein. Note=Localization to the mitochondrion is regulated by RNF186.

Molecular Weight: 26132

Clone: Polyclonal

Gene Name: BNIP1

Gene ID: 662

Function: As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311) . Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122) . It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122) . As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable) .

Summary: Tissue Location: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Vesicle transport protein SEC20, BCL2/adenovirus E1B 19 kDa protein-interacting protein 1, Transformation-related gene 8 protein, TRG-8, BNIP1, NIP1, SEC20L