NIT1 Antibody (C-term) [APR31062G]

NIT1 Antibody (C-term) [APR31062G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NIT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the C-terminal region of human NIT1.

Cellular Localisation: [Isoform 2]: Mitochondrion {ECO:0000250|UniProtKB:Q8VDK1}

Molecular Weight: 35896

Clone: Polyclonal

Gene Name: NIT1

Gene ID: 4817

Function: Catalyzes the hydrolysis of the amide bond in N- (4- oxoglutarate) -L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.

Summary: Tissue Location: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Nitrilase homolog 1, 35--, NIT1