NLRP3 Polyclonal Antibody | E-AB-70161

NLRP3 Polyclonal Antibody | E-AB-70161 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: AGTAVPRL, AII/AVP, Angiotensin/vasopressin receptor AII/AVP like, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, Caterpiller protein 1.1, CIAS 1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, LRR and PYD domains-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3, NALP3, NLR family pyrin domain containing 3, NLRP3, PYPAF 1, PYPAF1, PYRIN containing APAF1 like protein 1, PYRIN-containing APAF1-like protein 1

Application: IHC

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Cardiovascular, Immunology, Signal Transduction

Background: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Concentration: 0.65 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse NLRP3

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: IHC 1:300-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A