Noggin polyclonal Antibody | BS90954

Noggin polyclonal Antibody | BS90954 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Rat

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Genetic differentiation of the vertebrate somite necessitates a balance of inductive signals and antagonists. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGFβ) superfamily of signaling proteins, such as bone morphogenetic proteins-2, 4, 7 (BMP2, BMP4, BMP7) . Inhibition of BMP signaling by axially secreted Noggin mediates normal vertebrate skeletogenesis and patterning of the neural tube and somite. Spatially, Noggin may effectively antagonize BMP activity by efficiently diffusing through extracellular matrices, thereby creating morpho-genic gradients. Mice embryos that are homozygous null for Noggin, a lethal genotype, display stubby, continuous limbs with lack of joints in the paws and an array of other developmental defects.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Noggin polyclonal Antibody detects endogenous levels of Noggin protein.

Molecular Weight: 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NOG, Nog, NOGG, Noggin, SYM 1, SYM1, Symphalangism 1 (proximal), Synostoses (multiple) syndrome 1, SYNS 1, SYNS1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified

Pathway: