Notch 2 polyclonal Antibody | BS7044

Notch 2 polyclonal Antibody | BS7044 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IP

Application Range: WB: 1:500~1:1000 IP:1:500~1:1000

Background: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) . Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Notch2 is a member of the Notch family and mutation in Notch2 is associated with Alagille syndrome.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Notch 2 polyclonal Antibody detects endogenous levels of Notch 2 protein.

Molecular Weight: ~ 110/260kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Notch 2;Hn2;N2ECD;N2ICD;NOTCH2

Immunogen: Synthetic peptide, corresponding to Human Notch 2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Apoptosis,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,