NOTCH3 Polyclonal Antibody | E-AB-12817

NOTCH3 Polyclonal Antibody | E-AB-12817 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: CADASIL, CASIL, NOTC3, Notch 3, Notch 3 intracellular domain, Notch homolog 3, Notch3

Application: WB, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells

Background: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Concentration: 0.3 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human NOTCH3

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:200-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 244 kDa

Molecular Weight(Observed): N/A