NOTUM Antibody (C-term) [APR14146G]

NOTUM Antibody (C-term) [APR14146G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NOTUM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-379 amino acids from the C-terminal region of human NOTUM.

Cellular Localisation: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.

Molecular Weight: 55699

Clone: Polyclonal

Gene Name: NOTUM (HGNC:27106)

Gene ID: 147111

Function: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175) .

Summary: Tissue Location: Rarely expressed in adult normal tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein notum homolog, 3---, NOTUM