LBD
NPC1 Antibody (Center) [APR31121G]
- SKU:
- LBD-APR31121G
- Availability:
- Usually ships in 5 working days
Description
NPC1 Antibody (Center) [APR31121G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This NPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-620 amino acids from the Central region of human NPC1.
Cellular Localisation: Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein
Molecular Weight: 142167
Clone: Polyclonal
Gene Name: NPC1 (HGNC:7897)
Gene ID: 4864
Function: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680) . Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760) . Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754) . Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IF, IHC-P
Dilution: WB--1:2000 WB--1:1000 IF--1:10~50 IHC-P--1:100~500
Synonyms: Niemann-Pick C1 protein, NPC1