NQO2 polyclonal Antibody | BS90963

NQO2 polyclonal Antibody | BS90963 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB

Application Range: WB:1:1,000-1:2,000

Background: NAD (P) H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity. NQO2 is a 231 amino acid protein and is 43 amino acids shorter than NQO1 at its C-terminus. NQO2 is an isozyme of NQO1 and transfers two electrons to a quinone, resulting in the formation of a hydroquinone product . The NQO2 gene is ubiquitously expressed and induced in response to TCDD. NQO2 has a higher level of expression in mouse liver and testis than NQO1, which is highly expressed in the heart. NQO2 has a different cofactor requirement than NQO1 and uses dihydronicotinamide riboside (NRH) rather than NAD (P) H as an electron donor. Unlike NQO1, NQO2 is resistant to typical inhibitors of NQO1 such as dicoumarol, Cibacron blue and phenindonee, but is inhibited by quercetin and benzo (a) pyrene. NQO2 contains a specific metal binding site, which is absent in NQO1 and several cis-elements including SP1 binding sites, CCAAT box, XRE and ARE, which are located at the NQO2 gene promoter.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NQO2 polyclonal Antibody detects endogenous levels of NQO2 protein.

Molecular Weight: 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: QR2, NQO2, DHQV, DIA6, EC 1.10.99.2, MGC94180, NAD (P) H dehydrogenase quinone 2, NAD (P) H menadione oxidoreductase 1 dioxin inducible 2, NAD (P) H menadione oxidoreductase 2 dioxin inducible, NMOR2, NQO 2, NQO2, NQO2, NRH dehydrogenase [quinone] 2, NRH dehydrogenase, NRH:quinone oxidoreductase 2, OTTHUMP00000015948, OTTHUMP00000015949, OTTHUMP00000015953, Ox 2, Ox2, QR2, Quinone, Quinone reductase 2, Ribosyldihydronicotinamide dehydrogenase [quinone], Ribosyldihydronicotinamide dehydrogenase,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: