NR1H3 Polyclonal Antibody | E-AB-40217

NR1H3 Polyclonal Antibody | E-AB-40217 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Liver X receptor alpha, LXR a, LXRA, NR1H3, NR1H3_HUMAN, Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR alpha, Oxysterols receptor LXR-alpha, RLD 1, RLD1

Application: IHC

Reactivity: Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cardiovascular, Signal Transduction, Epigenetics and Nuclear Signaling, Signal Transduction, Cancer, Metabolism

Background: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Rat Oxysterols receptor LXR-alpha protien

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Affinity purification

Dilution: IHC 1:100-1:400

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A