NR2E1 Antibody (Center) [AMM06809G]

NR2E1 Antibody (Center) [AMM06809G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NR2E1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the Central region of human NR2E1.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.

Molecular Weight: 42589

Clone: Polyclonal

Gene Name: NR2E1

Gene ID: 7101

Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity) . May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity) . May be involved in retinoic acid receptor (RAR) regulation in retinal cells.

Summary: Tissue Location: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX