NS-3763 | B1814

NS-3763 is a selective non-competitive kainate receptor antagonist. It displays selectivity for GLUK5 subunit-containing receptors (IC₅₀ values are 1.6 and > 30 mM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC₅₀ > 30 μM).

NS-3763 is a selective non-competitive kainate receptor antagonist. It displays selectivity for GLUK5 subunit-containing receptors (IC₅₀ values are 1.6 and > 30 mM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC₅₀ > 30 μM).

B1814 | NS-3763 DataSheet

Alternate Name/Synonyms: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid

Appearance: Off-white solid

Formulation: N/A

CAS Number: 70553-45-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₁₆N₂O₆

Molecular Weight: 404.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO ( ~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective non-competitive kainate receptor antagonist

MDL Number: MFCD00334657

PubChem CID: 4359312

SMILES: C1=CC=C(C=C1)C(=O)NC2=CC(=C(C=C2C(=O)O)C(=O)O)NC(=O)C3=CC=CC=C3

InChi: InChI=1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)

InChi Key: UUDYZUDTQPLDDP-UHFFFAOYSA-