NSC-687852 | 2021

Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

NSC-687852 abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

2021 | NSC-687852 DataSheet

Alternate Name/Synonyms: 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 1009817-63-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₇N₃O₆

Molecular Weight: 419.39

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ubiquitin C-terminal hydrolase 5 (UCHL5) inhibitor

MDL Number: N/A

PubChem CID: 5351435

SMILES: C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1

InChi: InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22 (27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+, 18-12+

InChi Key: GFARQYQBWJLZMW-JYFOCSDGSA-N