NSC-87877 | 2687

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

2687 | NSC-87877 DataSheet

Alternate Name/Synonyms: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid

Appearance: Black solid

Formulation: N/A

CAS Number: 56990-57-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₃N₃O₇S₂

Molecular Weight: 459.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O (~20 mg/ml) or DMSO (~ 5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent SHP-1/SHP-2 protein tyrosine phosphatases inhibitor

MDL Number: MFCD09971104

PubChem CID: 5459322

SMILES: C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)C=C2S(=O)(=O)O)N=C1

InChi: InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,21H,(H,24,25,26)(H,27,28,29)/b22-16+

InChi Key: BIQBDHSYQMHHPU-CJLVFECKSA-N