Description
NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone. NSC109116 is a salicylic compound that selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2. It potently inhibits the metabolism of progesterone in bovine aortic endothelial cells overexpressing AKR1C1 with an IC₅₀ of 460 nM.
NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone. NSC109116 is a salicylic compound that selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2. It potently inhibits the metabolism of progesterone in bovine aortic endothelial cells overexpressing AKR1C1 with an IC₅₀ of 460 nM.
Alternate Name/Synonyms: 3-bromo-5-phenylsalicylic acid; 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid; 3-bromo-2-hydroxy-5-phenylbenzoic acid; AKR1C1 Inhibitor; Aldo-Keto Reductase family 1 member C1 Inhibitor; 5-PBSA
Appearance: A crystalline solid
Formulation:
CAS Number: 4906-68-7
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₃H₉BrO₃
Molecular Weight: 293.1
Cell-Permeable?: True
Purity: >97%
Solubilities: ~0.1 mg/ml in in Ethanol, ~12.5 mg/ml in in DMSO, ~15 mg/ml in DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of AKR1C1
MDL Number: MFCD18378258
PubChem CID: 268734
SMILES: C1=CC=C(C=C1)C2=CC(=C(C(=C2)Br)O)C(=O)O
InChi: InChI=1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17)
InChi Key:
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |