NSD1 Antibody | 24-011

NSD1 Antibody | 24-011 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human NSD1 (NP_071900.2) .

Research Area: Other

Tested Application: WB

Application: WB: 1:500 - 1:1000

Specificiy: N/A

Positive Control 1: 293T

Positive Control 2: A-549

Positive Control 3: MCF7

Positive Control 4: SW480

Positive Control 5: Mouse kidney

Positive Control 6: Mouse lung

Molecular Weight: Observed: 297kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: ARA267, KMT3B, SOTOS, SOTOS1, STO, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, H3-K36-HMTase, H4-K20-HMTase, NR-binding SET domain-containing protein, androgen receptor coactivator 267 kDa protein, androgen receptor-associated coregulator 267, androgen receptor-associated protein of 267 kDa, lysine N-methyltransferase 3B, nuclear receptor SET domain-containing protein 1, nuclear receptor-binding SET domain-containing protein 1, truncated nuclear receptor binding SET domain protein 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs) , 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.