NUDT1 Antibody, KO Validated | 14-924

NUDT1 Antibody, KO Validated | 14-924 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human NUDT1 (NP_945192.1) .

Research Area: Other

Tested Application: WB, IHC, IP

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IP: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: SW480

Positive Control 2: K562

Positive Control 3: 22RV1

Positive Control 4: THP-1

Positive Control 5: HepG2

Positive Control 6: SKOV3

Molecular Weight: Observed: 18kDa

Validation: Antibody is Knockout validated.

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: MTH1, 7, 8-dihydro-8-oxoguanine triphosphatase, 2-hydroxy-dATP diphosphatase, 8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase, 8-oxo-7, 8-dihydroguanosine triphosphatase, 8-oxo-dGTPase, mutT human homolog 1, nucleoside diphosphate-linked moiety X motif 1, nucleoside diphosphate-linked moiety X-type motif 1, nudix (nucleoside diphosphate linked moiety X) -type motif 1, nudix motif 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.