NUMB polyclonal Antibody | BS90976

NUMB polyclonal Antibody | BS90976 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:100

Background: Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR) . Mammalian NUMB homologs play a role in the determination of cell fates during development and bind with EPS15, LNX1, and NOTCH1. Conditional mouse mutants with deletion of NUMB in developing sensory ganglia show a reduction in axonal arborization in afferent fibers. Changes in cellular calcium homeostasis influences NUMB-dependent cell fate decisions during development of the nervous system. Chicken NUMB (c-NUMB) protein is localized to the basal cortex of mitotic neuroepithelial cells.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NUMB polyclonal Antibody detects endogenous levels of NUMB protein.

Molecular Weight: 71 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: h-Numb, c14_5527, C14orf41, FLJ31314, h Numb, h-Numb, Numb, Numb homolog (Drosophila), Numb homolog, Numb protein homolog, NUMB, Protein numb homolog, Protein S171, S171,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: