Description
Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b), p53 pathway activator, and apoptosis inducer.
Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b), p53 pathway activator, and apoptosis inducer.
Alternate Name/Synonyms: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 548472-68-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₃₀Cl₂N₄O₄
Molecular Weight: 581.49
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: Mdm2 (mouse double minute 2) antagonist
MDL Number: MFCD07784509
PubChem CID: 216345
SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChi: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37) 17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChi Key: BDUHCSBCVGXTJM-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |
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