Nutlin-3b | B1227

Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2 cellular activities. Potency of Nutlin-3b is much lower in the wild type p53 cells and has no effect regardless of the status of p53 cells.

Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2 cellular activities. Potency of Nutlin-3b is much lower in the wild type p53 cells and has no effect regardless of the status of p53 cells.

B1227 | Nutlin-3b DataSheet

Alternate Name/Synonyms: 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 675576-97-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₀Cl₂N₄O₄

Molecular Weight: 581.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>14 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A useful negative control for for non-MDM2 cellular activities

MDL Number: N/A

PubChem CID: 16755649

SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChi: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1

InChi Key: BDUHCSBCVGXTJM-IZLXSDGUSA-N