NVP-BKM120 | 2619

NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and mammalian target of rapamycin (mTOR) and has no effect on PI4Kβ and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.

NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and mammalian target of rapamycin (mTOR) and has no effect on PI4Kβ and several other kinases.

2619 | NVP-BKM120 DataSheet

Alternate Name/Synonyms: (5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; BKM-120; Buparlisib

Appearance: White solid

Formulation: N/A

CAS Number: 944396-07-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₁F₃N₆O₂

Molecular Weight: 410.39

Cell-Permeable?: Yes

Purity: >95% by HPLC

Solubilities: DMSO (~15 mg/ml) or EtOH (~15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PI3K inhibitor

MDL Number: N/A

PubChem CID: 16654980

SMILES: C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

InChi: InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)

InChi Key: CWHUFRVAEUJCEF-UHFFFAOYSA-N