NVS-SM1 | B1844

NVS-SM1, also known as LMI070, is a highly potent, selective small molecule SMN2 splicing modulator with potential for treating spinal muscular atrophy. It works by increasing the amount of functional survival of motor neuron protein produced by the SMN2 gene through modifying its splicing pattern.

NVS-SM1, also known as LMI070, is a highly potent, selective small molecule SMN2 splicing modulator with potential for treating spinal muscular atrophy. It works by increasing the amount of functional survival of motor neuron protein produced by the SMN2 gene through modifying its splicing pattern.

B1844 | NVS-SM1 DataSheet

Alternate Name/Synonyms: (6Z)-3-(1H-pyrazol-4-yl)-6-[3-(2,2,6,6-tetramethylpiperidin-4-yl)oxy-1H-pyridazin-6-ylidene]cyclohexa-2,4-dien-1-one; Branaplam; LMI070

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1562338-42-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₂₇N₅O₂

Molecular Weight: 393.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent, selective small molecule SMN2 splicing modulator

MDL Number: N/A

PubChem CID: 89971189

SMILES: CC1(CC(CC(N1)(C)C)OC2=NNC(=C3C=CC(=CC3=O)C4=CNN=C4)C=C2)C

InChi: InChI=1S/C22H27N5O2/c1-21(2)10-16(11-22(3,4)27-21)29-20-8-7-18(25-26-20)17-6-5-14(9-19(17)28)15-12-23-24-13-15/h5-9,12-13,16,25,27H,10-11H2,1-4H3,(H,23,24)/b18-17+

InChi Key: YIFFDXMJVNKGBL-ISLYRVAYSA-N