O-Benzyl-L-serine | B2152

O-Benzyl-L-serine (BenSer) is an inhibitor of the glutamine transporter ASCT2. BenSer significantly reduces both leucine and glutamine transport in melanoma cells, leading to inhibition of mTORC1 signaling. Cell proliferation and cell cycle progression are significantly reduced in the presence of BenSer in melanoma cells in 2D and 3D cell culture.

O-Benzyl-L-serine (BenSer) is an inhibitor of the glutamine transporter ASCT2. BenSer significantly reduces both leucine and glutamine transport in melanoma cells, leading to inhibition of mTORC1 signaling. Cell proliferation and cell cycle progression are significantly reduced in the presence of BenSer in melanoma cells in 2D and 3D cell culture.

B2152 | O-Benzyl-L-serine DataSheet

Alternate Name/Synonyms: (S)-2-Amino-3-benzyloxypropionic acid; BenSer

Appearance: Cystalline solid

Formulation: N/A

CAS Number: 4726-96-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₃NO₃

Molecular Weight: 195.22

Cell-Permeable?: Yes

Purity: ≥98% by titration

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A glutamine uptake inhibitor

MDL Number: MFCD00065937

PubChem CID: 78457

SMILES: C1=CC=C(C=C1)COCC(C(=O)O)N

InChi: InChI=1S/C10H13NO3/c11-9(10(12)13)7-14-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/m0/s1

InChi Key: IDGQXGPQOGUGIX-VIFPVBQESA-N