OASL Antibody | 7775

OASL Antibody | 7775 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL.
The immunogen is located within the first 50 amino acids of OASL.

Research Area: Homeostasis

Tested Application: E, WB, ICC, IF

Application: OASL antibody can be used for detection of OASL by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry at 2.5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: OASL antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1410 - Mouse Bladder Tissue Lysate

Positive Control 2: Cat. No. 17-011 - Hep G2 Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 57 kDa
Observed: 65 kDa

Validation: N/A

Isoform: N/A

Purification: OASL antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: OASL Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: OASL antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: OASL Antibody: OASLd, TRIP14, TRIP-14, p59OASL, p59 OASL, p59-OASL, Thyroid receptor-interacting protein 14, TR-interacting protein 14

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: OASL (2'-5'-oligoadenylate synthetase-like) , also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14) , is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1) . It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3) . Methyl CpG-binding protein 1 (MBD1) , which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4) .