OB-cadherin polyclonal Antibody | BS71086

OB-cadherin polyclonal Antibody | BS71086 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin β, to regulate cadherin function. Two forms of OB-cadherin (for osteoblast-cadherin, also designated cadherin-11 or OSF-4) have been identified as OBcadherin- 1 and OB-cadherin-2. Both OB-cadherins are expressed in osteoblastic cell lines and low expression is also seen in lungs, testis and brain. OB-cadherin-2 has a truncated cytoplasmic domain.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OB-cadherin polyclonal Antibody detects endogenous levels of OB-cadherin protein.

Molecular Weight: ~ 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: OB; CAD11; CDHOB; OSF-4;

Immunogen: Recombinant protein of human CDH11.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: