Oct-3/4 polyclonal Antibody | BS90981

Oct-3/4 polyclonal Antibody | BS90981 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC/IF IHC IP CHIP

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: POU5F1 (POU domain, class 5, transcription factor 1), also known as octamer-binding transcription factor-3 (Oct-3, OTF3), octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, modulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 sustains stem-cell self-renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Oct-3/4 polyclonal Antibody detects endogenous levels of Oct-3/4 protein.

Molecular Weight: 39 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Oct-4, Oct-3, OTF-3, POU5F1, OCT3, OCT4, OTF3, Octamer binding transcription factor 4, MGC22487, Oct 3, Oct 4, Oct-3, Oct-4, OCT3, Oct4, Octamer binding protein 3, Octamer binding protein 4, Octamer binding transcription factor 3, Octamer-binding protein 3, Octamer-binding protein 4, Octamer-binding transcription factor 3, OTF 3, OTF 4, OTF-3, OTF3, OTF4, PO5F1, POU class 5 homeobox 1, POU domain class 5 transcription factor 1, POU domain transcription factor OCT4, POU domain, class 5, transcription factor 1, POU-type homeodomain-containing DNA-binding protein, POU5F1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: