OICR-9429 | B1256

OICR-9429 is a small-molecule inhibitor of the WDR5-MLL interaction that effectively stops the growth of breast cancer cell lines driven by p53 gene mutation. It also stops the growth of subtype of leukemia cells having specific mutation found in about 9% of the patients with acute myeloid leukemia. WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.

OICR-9429 is a small-molecule inhibitor of the WDR5-MLL interaction that effectively stops the growth of breast cancer cell lines driven by p53 gene mutation. It also stops the growth of subtype of leukemia cells having specific mutation found in about 9% of the patients with acute myeloid leukemia. WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.

B1256 | OICR-9429 DataSheet

Alternate Name/Synonyms: N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4- ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1801787-56-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₉H₃₂F₃N₅O₃

Molecular Weight: 555.59

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of the WDR5-MLL interaction

MDL Number: N/A

PubChem CID: 91623360

SMILES: CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC(=CC=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F

InChi: InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)

InChi Key: DJOVLOYCGXNVPI-UHFFFAOYSA-N