Omeprazole | B3052

Omeprazole is a proton pump inhibitor (PPI). It inhibits gastric H+/K+ ATPase with an IC₅₀ of 1.1 μM. It shows competitive inhibition of cytochrome P450 enzyme CYP2C19 activity with a Ki of 2-6 μM. It is used for the treatment of gastroesophageal reflux disease and peptic ulcer. It is in clinical trials for treating complications of COVID-19.

Omeprazole is a proton pump inhibitor (PPI). It inhibits gastric H+/K+ ATPase with an IC₅₀ of 1.1 μM. It shows competitive inhibition of cytochrome P450 enzyme CYP2C19 activity with a Ki of 2-6 μM. It is used for the treatment of gastroesophageal reflux disease and peptic ulcer. It is in clinical trials for treating complications of COVID-19.

B3052 | Omeprazole DataSheet

Alternate Name/Synonyms: 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole; 5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole; Prilosec; Losec

Appearance: White solid

Formulation:

CAS Number: 73590-58-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₇H₁₉N₃O₃S

Molecular Weight: 345.42

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~30 mg/ml in DMSO and DMF, ~5 mg/ml in ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A proton pump inhibitor

MDL Number: MFCD00083192

PubChem CID: 4594

SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC

InChi: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChi Key: SUBDBMMJDZJVOS-UHFFFAOYSA-N