ONO 1078 | B1099

ONO-1078 is a novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro. It also shows concentration dependent inhibition and reverses contraction of isolated human bronchus induced by LTC4 and LTD4 and antigen. ONO-1078 was 100 times more potent than FPL-55712 in inhibiting LTC4 induced contractions.

ONO-1078 is a novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro. It also shows concentration dependent inhibition and reverses contraction of isolated human bronchus induced by LTC4 and LTD4 and antigen. ONO-1078 was 100 times more potent than FPL-55712 in inhibiting LTC4 induced contractions.

B1099 | ONO 1078 DataSheet

Alternate Name/Synonyms: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide

Appearance: White Solid

Formulation: N/A

CAS Number: 103177-37-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₃N₅O₄

Molecular Weight: 481.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A novel leukotriene antagonist that inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4

MDL Number: MFCD00864631

PubChem CID: 4887

SMILES: 1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC4=C(C=C3)C(=O)C=C(O4)C5=NNN=N5

InChi: InChI=1S/C27H23N5O4/c33-23-17-25(26-29-31-32-30-26)36-24-16-20(11-14-22(23)24)28-27(34)19-9-12-21(13-10-19)35-15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-14,16-17H,4-5,8,15H2,(H,28,34)(H,29,30,31,32)

InChi Key: UAJUXJSXCLUTNU-UHFFFAOYSA-N