OPN (L285) polyclonal Antibody | BS1264

OPN (L285) polyclonal Antibody | BS1264 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Osteopontin (OPN), also designated bone sialoprotein 1, urinary stone protein, spp-1, Eta-1, nephropontin and uropontin, is an extracellular matrix cell adhesion phosphoglycoprotein. OPN is deposited into unmineralized matrix prior to calcification leading to localization at various tissue interfaces including cement lines, lamina limitans and between collagen fibrils of fully matured hard tissues. While OPN is a major product of osteoblasts, it is also synthesized by brain and kidney cells. OPN isolated from or secreted by various tissues ranges in molecular weight due to posttranslational modifications. OPN functions as a substrate for transglutaminase and is involved in cell adhesion, chemoattraction and immunomodulation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OPN (L285) polyclonal Antibody detects endogenous levels of OPN protein.

Molecular Weight: ~ 35, 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: BNSP; Bone sialoprotein 1; BSP I; BSPI; Early T lymphocyte activation 1; ETA 1; ETA1; Nephropontin; OPN; Osteopontin; OSTP; Secreted phosphoprotein 1; SPP 1; SPP-1; SPP1; Urinary stone protein; Uropontin;

Immunogen: Synthetic peptide, corresponding to amino acids 251-300 of Human OPN.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Cell Cycle Control G1 S Checkpoint,