OR2AT4 Antibody (C-term) [APR30867G]

OR2AT4 Antibody (C-term) [APR30867G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This OR2AT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the C-terminal region of human OR2AT4.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 35503

Clone: Polyclonal

Gene Name: OR2AT4 {ECO:0000303|PubMed:24999593, ECO:0000312|HGNC:HGNC:19620}

Gene ID: 341152

Function: Olfactory receptor (PubMed:24999593, PubMed:30228264) . Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264) . Endogenous ligand is unknown (Probable) . The activity of this receptor is propably mediated by G proteins which induce elevation of intracellular Ca (2+), a cAMP- dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264) . Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593) . Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264) .

Summary: Tissue Location: Detected in the keratinocytes of the epidermis (at protein level) (PubMed:24999593) . Detected in hair follicles in proximal outer root sheath and hair matrix keratinocytes (at protein level) (PubMed:30228264) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Olfactory receptor 2AT4, Olfactory receptor OR11-265, OR2AT4