Orlistat | B1020

Orlistat is a cell-permeable, selective, and competitive lipase inhibitor (IC₅₀ = 0.15 µM). Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways. Displays antiobesity and antihypercholesterolemic activity in vivo.

Orlistat is a cell-permeable, selective, and competitive lipase inhibitor (IC₅₀ = 0.15 µM). Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways. Displays antiobesity and antihypercholesterolemic activity in vivo.

B1020 | Orlistat DataSheet

Alternate Name/Synonyms: N-Formyl-L-leucine (1S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; Tetrahydrolipstatin

Appearance: White solid

Formulation: N/A

CAS Number: 96829-58-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₅₃NO₅

Molecular Weight: 495.73

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective, and competitive lipase inhibitor

MDL Number: MFCD05662360

PubChem CID: 3034010

SMILES: CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O

InChi: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

InChi Key: AHLBNYSZXLDEJQ-FWEHEUNISA-N