ORP150 polyclonal Antibody | BS90991

ORP150 polyclonal Antibody | BS90991 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC FC

Application Range: WB:1:5,000-1:20,000 IHC:1:50-1:200 FC:1:50-1:100

Background: ORP150, also known as HYOU1 (hypoxia upregulated 1), is a 999 amino acid protein that localizes to the lumen of the endoplasmic reticulum (ER) and is a member of the heat shock protein 70 (HSP 70) family. ORP150 is highly expressed in tissues that have well-developed ERs and a large number of secretory proteins (such as liver and pancreas) . It is expressed at lower levels in kidney and brain, and plays an essential role in cytoprotective cellular responses to hypoxia (oxygen deprivation) . Specifically, ORP150 participates in protein folding and secretion in the ER and functions to protect cells from hypoxia-induced apoptosis, thereby playing a crucial role in cell survival. ORP150 expression is upregulated in a variety of tumors, such as breast cancer, suggesting an important role in tumorigenesis. The gene encoding ORP150 has two translation initiation sites, resulting in a truncated transcript that lacks an ER signal peptide, but is thought to function as a housekeeping protein in the cytoplasm.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: ORP150 polyclonal Antibody detects endogenous levels of ORP150 protein.

Molecular Weight: 111 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ORP-150, GRP-170, HYOU1, GRP170, ORP150, 150 kDa oxygen regulated protein, 150 kDa oxygen-regulated protein, 170 kDa glucose regulated protein, 170 kDa glucose-regulated protein, DKFZp686N08236, FLJ94899, FLJ97572, glucose regulated protein 170, Grp 170, GRP-170, Grp170, HSP 12A, HSP12A, Hyou1, HYOU1, Hypoxia up regulated 1, hypoxia up-regulated 1 precursor, Hypoxia up-regulated protein 1, Hypoxia upregulated 1, Orp 150, ORP-150, Orp150, oxygen regulated protein (150kD),

Immunogen: Recombinant protein within human ORP150 aa 800-950.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: