Oseltamivir . phosphate | 10-036

Oseltamivir . phosphate | 10-036 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 312.4 . 98.0

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: GS-4104; Ro 64-0796/002; Tamiflu

Background: Oseltamivir phosphate is an influenza viral neuraminidase inhibitor. It is an antiviral prodrug targeted against the influenza viruses. Once hydrolyzed in the liver to its active metabolite, oseltamivir carboxylate, it can competitively inhibit viral neuraminidase (IC50s=0.1-4.9nM for influenza neuraminidases A and B) . The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir is blocking the release of new viral particles from a host cell. Oseltamivir phosphate is used clinically to treat influenza A and influenza B and to prevent flu after exposure. It potentially could be used to reduce the spread of the SARS-CoV-2 and counteract against the transmission of COVID-19

Disclaimer: This product is for research use only.

Purity: greater than or equal to 98% (HPLC)

Formula: C16H28N2O4 . H3PO4

Source: N/A

Solubility: Soluble in DMSO (50mg/ml) .

InChi Key: POPJIXMLXGJJOV-ZFSDTUNKSA-N

Smiles: O=P (OO) =O.N[C@@H]1[C@@H] (NC (C) =O) [C@H] (OC (CC) CC) C=C (C (OCC) =O) C1.[HH]

RTECS: N/A

Identity: Determined by 1H-NMR.

Merck Index: N/A