OSU-03012 | 2295

A novel celecoxib derivative, that acts as a potent inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1) activity (IC₅₀ = 5 µM for recombinant PDK1). It displays anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase(PI3K)/Akt pathway. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.

OSU-03012 is a potent inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1) activity (IC₅₀ = 5 µM for recombinant PDK1).

2295 | OSU-03012 DataSheet

Alternate Name/Synonyms: 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide; OSU03012; AR-12

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 742112-33-0

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₆H₁₉F₃N₄O

Molecular Weight: 460.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PDK1 inhibitor

MDL Number: MFCD12912272

PubChem CID: 10027278

SMILES: C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F

InChi: InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)

InChi Key: YULUCECVQOCQFQ-UHFFFAOYSA-N