Otoraplin (OTOR), human recombinant | 4987

TOR proteins is also known as fibrocyte-derived protein (Fdp) and Melanoma inhibitory activity-like (MIAL). Otoraplin is a member of the melanoma-inhibiting activity gene family. Otoraplin is a secreted 16 kDa globular protein that is expressed in the inner ear by periotic mesenchyme and developing and mature fibrocytes. OTOR is highly homologous to MIA/cartilage-derived retinoic acid-sensitive protein (CD-RAP), which is a cartilage-specific protein that is also expressed in malignant melanoma cells. The 111 amino acid mature human otoraplin contains 1 SH3 domain (46 –107 amino acids) and a Tyr at position 50 that is reportedly sulfated. Otoraplin takes part in the initiation of periotic mesenchyme chondrogenesis. Otoraplin is secreted through the Golgi apparatus and plays a role in cartilage development and maintenance. A frequent polymorphism in the translation start codon of OTOR can abolish translation and may be associated with forms of deafness. Recombinant human Otoraplin produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids and having a molecular mass of 12.7 kDa.The OTOR is purified by proprietary chromatographic techniques.

4987 | Otoraplin OTOR human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Otoraplin, Fibrocyte-derived protein, Melanoma inhibitory activity-like protein, OTOR, MIAL, FDP, MIAL1, MGC126737, MGC126739,

Alternates names: Jacalin

Taglines: Functions in cartilgae development and maintainence

NCBI Gene ID #: N/A

NCBI Gene Symbol: N/A

Gene Source: N/A

Accession #: Q38720

Recombinant: Yes

Source: Artocarpus heterophyllus (Jackfruit)

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity:

Assay #2:

Endotoxin Level: < 0.1 EU/mg

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity:

Unit Definition: N/A

Molecular Weight: 14.6 kDa ( chain) and 17.1 kDa (full protein)

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized without additives

Reconstitution Instructions: Reconstitute in water

Amino acid sequence: MAYSSLLSLS VLALLFSISS ADTRKWFLAN GINQNPIGII EAAVGVSEDL LNLNGMEAKN NKQSGKSQTV IVGPWGAQVS TSSNGKAFDD GAFTGIREIN LSYNKETAIG DFQVIYDLNG SPYVGQNHTS FIKGFTPVKI SLDFPSEYIV DVSGYTGKVS GYVVVRSLTF TNKKTYGPY GVTSGTPFNL PIENGLVVGF KGSIGYWLDY FSMYLSL