OXSR1 polyclonal Antibody | BS5837

OXSR1 polyclonal Antibody | BS5837 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Oxidative stress-responsive 1 protein (OXSR1), a protein of 527 amino acids, belongs to the STE20 subfamily. OXSR1 is one of two human homologs of Fray, a serine/threonine kinase expressed in Drosophila. OXSR1 binds to and phosphorylates p21-activated protein kinase PAK1 and regulates downstream kinases in response to environmental stress. Endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 may also play a role in regulating the actin cytoskeleton. The chloride channel proteins SLC12A1, SLC12A2, and SLC12A6 isoform 2 interact with OXSR1, but SLC12A4 and SLC12A7 do not. The WNK1 and WNK4 protein kinases activate OXSR1 by phosphorlating its T-loop. The OXSR1 protein is widely expressed in mammalian tissues.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OXSR1 polyclonal Antibody detects endogenous levels of OXSR1 protein.

Molecular Weight: ~ 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Serine/threonine-protein kinase OSR1; Oxidative stress-responsive 1 protein; KIAA1101; OSR1

Immunogen: Synthetic peptide, corresponding to amino acids 312-357 of Human OXSR1.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A