Oxythiamine Chloride Hydrochloride | B1046

Oxythiamine is a thiamine antagonist that acts as a transketolase inhibitor. As transketolase is a crucial enzyme of the pentose phosphate pathway, inhibition of this enzyme causes suppression of the pentose phosphate pathway and thus deprives cells of the metabolic intermediate (glyceraldehyde-3-phosphate) for ATP generation and of the substrates (NADPH, ribose-phosphate) for macromolecule synthesis. This metabolic inhibition seems to be responsible, at least in part, for the significant anticancer activity observed in vitro and in vivo.

Oxythiamine is a thiamine antagonist that acts as a transketolase inhibitor. As transketolase is a crucial enzyme of the pentose phosphate pathway, inhibition of this enzyme causes suppression of the pentose phosphate pathway and thus deprives cells of the metabolic intermediate (glyceraldehyde-3-phosphate) for ATP generation and of the substrates (NADPH, ribose-phosphate) for macromolecule synthesis. This metabolic inhibition seems to be responsible, at least in part, for the

B1046 | Oxythiamine Chloride Hydrochloride DataSheet

Alternate Name/Synonyms: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride

Appearance: White solid

Formulation: N/A

CAS Number: 614-05-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₆ClN₃O₂S.HCl

Molecular Weight: 338.25

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A thiamine antagonist that acts as a transketolase inhibitor.

MDL Number: MFCD00050656

PubChem CID: 56845140

SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N=O)C)CCO.Cl.[Cl-]

InChi: InChI=1S/C12H15N4O2S.2ClH/c1-8-11(3-4-17)19-7-16(8)6-10-5-13-9(2)14-12(10)15-18;;/h5,7,17H,3-4,6H2,1-2H3;2*1H/q+1;;/p-1

InChi Key: BNURZUBKXXZBQE-UHFFFAOYSA-M