p-MSN; RDX; EZR (T558) polyclonal Antibody | BS65022

p-MSN; RDX; EZR (T558) polyclonal Antibody | BS65022 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat,Mouse

Application: WB

Application Range: WB: 1:500~1:1000

Background: The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regulating ERM protein conformation and function. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MSN; RDX; EZR (phospho-T558) polyclonal Antibody detects endogenous levels of MSN; RDX; EZR (phospho-T558) protein.

Molecular Weight: ~ 75,80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Moesin; Membrane-organizing extension spike protein; MSN; Radixin; RDX; Ezrin; Cytovillin; Villin-2; p81; EZR

Immunogen: Synthetic peptide, corresponding to Human MSN; RDX; EZR (phospho-T558) .

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: