p15 INK4b (G113) polyclonal Antibody | BS1267

p15 INK4b (G113) polyclonal Antibody | BS1267 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: p15 (PAF), also known as PAF, L5, OEATC1 (overexpressed in anaplastic thyroid carcinoma 1) or NS5ATP9, is a 111 amino acid protein that localizes to both the nucleus and the mitochondria. Highly expressed in colon and thymus with lower expression in liver, ovary, kidney, spleen, placenta and small intestine, p15 (PAF) interacts with the nuclear antigen PCNA and, through this interaction, is thought to protect cells from UV-induced cell death. The association of p15 (PAF) and PCNA is enhanced by UV treatment and is facilitated by the binding of ING1, a tumor suppressor that can induce apoptosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p15 INK4b (G113) polyclonal Antibody detects endogenous levels of p15 INK4b protein.

Molecular Weight: ~ 15 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; P15ink4b; CDKN2B; MTS2

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human p15 INK4b.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Cell Cycle Control G1 S Checkpoint,