p16 INK4a/CDKN2A polyclonal Antibody | BS90998

p16 INK4a/CDKN2A polyclonal Antibody | BS90998 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: p16 INK4a/CDKN2A polyclonal Antibody detects endogenous levels of p16 INK4a/CDKN2A protein.

Molecular Weight: 17 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CDK4I, MTS-1, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1, CCM2, CDK4 inhibitor p16 INK4, CDK4I, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM2, Cyclin dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4), Cyclin Dependent Kinase Inhibitor 2A, Cyclin dependent kinase inhibitor 2A isoform 4, Cyclin dependent kinase inhibitor 2A isoforms 1/2/3, Cyclin dependent kinase inhibitor p16, INK4, INK4A, MLM, MTS1, Multiple tumor suppressor 1, p14, p16, P16INK4, p16INK4a, p19, p19Arf, TP16,

Immunogen: Synthetic peptide within C-terminal human CDKN2A/p16INK4a.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: