PAFAH1B2 Antibody (Center) [APR08917G]

PAFAH1B2 Antibody (Center) [APR08917G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PAFAH1B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the Central region of human PAFAH1B2.

Cellular Localisation: Cytoplasm.

Molecular Weight: 25569

Clone: Polyclonal

Gene Name: PAFAH1B2 (HGNC:8575)

Gene ID: 5049

Function: Alpha2 catalytic subunit of the cytosolic type I platelet- activating factor (PAF) acetylhydrolase (PAF-AH (I) ) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3- phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2- acetyl-sn-glycero-3-phosphoric acid (AAGPA) . In contrast, the alpha1/alpha2 heterodimer (PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity) . May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity) .

Summary: Tissue Location: Ubiquitous..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Platelet-activating factor acetylhydrolase IB subunit beta, PAF acetylhydrolase 30 kDa subunit, PAF-AH 30 kDa subunit, PAF-AH subunit beta, PAFAH subunit beta, PAFAH1B2, PAFAHB